1) A focal infection was prepared by inoculation
of staphylococci into rat gingiva. Then, concentrations in
oral tissues (gingiva, tongue and masseter), serum and liver
of the infected rats which were given ciclacillin, ampicillin,
cephalexin and minocycline in a dose of 100 mg/kg p.o. were
investigated and effects of serratiopeptidase (20 mg/kg) on
these concentrations were studied.
2) Concentrations of ciclacillin
in the oral tissues were approximately 10% of a serum level.
A gingival concentration was elevated 8.5-fold by pretreatment
with serratiopeptidase. A concentration in infected gingiva
was 2.5-fold of that of another side of gingiva.
3) Concentrations
of ampicillin in the oral tissues were approximately
15% of a serum level. A gingival concentration was elevated
5.7-fold by pretreatment with serratiopeptidase. A concentration
in infected gingiva ws 2.2-fold of that of another side
of gingiva.
4) Concentrations of cephalexin in the oral tissues
were approximately 3 to 5-fold of a serum level except
that in masseter. A gingival concentration was slightly
elevated (1.1-fold) by pretreatment with serratiopeptidase.
A concentration in infected gingiva was 1.7-fold of that
of another side of gingiva.
5) Concentrations of minocycline
in the oral tissues were 1.3 to 7.2-fold of a serum level.
A gingival concentration was elevated 2.2-fold by pretreatment
with serratipeptidase. A concentration in infected gingiva
was 3.1-fold of that of another side of gingiva.
6) Gingival
concentrations of antibiotics were higher than those
of tongue and masseter and serratiopeptidase elevated
gingival concentrations. |
